Always inform your doctor about all medications you take, including over-the-counter drugs, supplements, and herbal remedies, before starting sildenafil. This helps prevent potentially harmful interactions.
Nitrates, commonly used to treat angina (chest pain), interact dangerously with sildenafil. This combination can cause a significant drop in blood pressure, leading to dizziness, fainting, or even heart attack. Avoid using sildenafil if you’re on nitrate medication.
Alpha-blockers, prescribed for high blood pressure or enlarged prostate, can also lower blood pressure when combined with sildenafil. Your doctor may adjust your dosages or suggest alternatives to ensure your safety.
Certain antifungals, like ketoconazole and itraconazole, can increase sildenafil levels in your blood, potentially intensifying side effects. Your doctor might recommend a lower sildenafil dose.
Strong CYP3A4 inhibitors, such as some HIV medications (ritonavir, indinavir), also raise sildenafil blood levels. This necessitates careful monitoring and potential dose adjustment.
Conversely, medications that induce CYP3A4, like rifampin (used for tuberculosis), can lower sildenafil levels, reducing its effectiveness. Your doctor might need to adjust your dosage accordingly.
Sildenafil can interact with other medications affecting blood clotting. Discuss any anticoagulants or antiplatelet drugs you’re using with your physician before taking sildenafil.
This information is not exhaustive. Consult your doctor or pharmacist for personalized advice on potential drug interactions, especially if you have pre-existing health conditions or take multiple medications.
