Sildenafil citrate, the active component of Viagra, works by inhibiting an enzyme called phosphodiesterase-5 (PDE5). This enzyme breaks down cyclic guanosine monophosphate (cGMP), a crucial molecule for achieving and maintaining an erection. By blocking PDE5, sildenafil allows cGMP levels to increase, leading to relaxation of smooth muscles in the penis and improved blood flow. This increased blood flow facilitates an erection in response to sexual stimulation.
How Sildenafil Differs from Other PDE5 Inhibitors
While sildenafil is the most well-known PDE5 inhibitor, several others exist, each with slightly varying characteristics. Key differences often relate to onset of action, duration of effect, and potential side effects. These variations allow doctors to tailor treatment to individual patient needs.
- Tadalafil (Cialis): Known for its longer duration of action. Vardenafil (Levitra): Often considered to have a faster onset of action. Avanafil (Stendra): May offer a quicker onset than sildenafil.
Potential Side Effects and Precautions
Sildenafil, like other medications, can cause side effects. Common side effects include headache, flushing, nasal congestion, and visual disturbances. However, these are generally mild and temporary. More serious side effects are rare but require immediate medical attention. Individuals with certain pre-existing conditions, such as heart disease or low blood pressure, should consult their doctor before using sildenafil. Always follow your doctor’s instructions carefully and discuss any concerns about side effects or interactions with other medications.
Always inform your doctor about your complete medical history. Follow prescribed dosage instructions precisely. Seek immediate medical help for any concerning symptoms.
