Sildenafil, the active ingredient in Viagra and other medications, primarily targets the enzyme phosphodiesterase-5 (PDE5).
PDE5 Inhibition and Blood Flow
PDE5 breaks down a molecule called cyclic GMP (cGMP), which plays a crucial role in blood vessel relaxation. By inhibiting PDE5, sildenafil allows cGMP levels to rise. This increased cGMP causes the smooth muscles in blood vessels to relax, leading to improved blood flow, particularly in the penis.
Sexual Stimulation is Key
It’s important to understand that sildenafil doesn’t cause an erection on its own. Sexual stimulation is necessary to trigger the release of nitric oxide, which then initiates the cGMP pathway. Sildenafil simply enhances the body’s natural response to this stimulation.
Dosage Considerations: 50mg vs 100mg
- 50mg: Often a starting dose. It’s generally well-tolerated and effective for many men. Your doctor may recommend starting here to assess your individual response. 100mg: A higher dose, used if 50mg proves insufficient. Your doctor will carefully consider the potential side effects before prescribing this higher dose.
The optimal dose varies from person to person, depending on factors like age, overall health, and other medications being taken.
Understanding Potential Side Effects
Headache Facial flushing Indigestion Nasal congestion
These are common and usually mild. More serious side effects are rare but require immediate medical attention. Always consult your doctor about any concerns.
Individualized Treatment
Dosage adjustments are common. Your doctor will help determine the right dose and monitor your progress. Open communication with your doctor is critical for safe and effective treatment.
