Pletal, containing cilostazol, improves blood flow in your legs and feet by widening blood vessels. This helps alleviate symptoms of peripheral artery disease (PAD), such as pain, numbness, and cramping, especially during exercise (claudication).
How Cilostazol Works
Cilostazol works in two ways: it inhibits an enzyme called phosphodiesterase III, leading to increased blood vessel dilation, and it inhibits platelet aggregation, preventing blood clots that further restrict blood flow. This dual mechanism provides a more comprehensive approach to managing PAD.
Dosage and Administration
Your doctor will prescribe the appropriate dosage. Commonly, this is 100 mg twice daily, taken with food. Always follow your doctor’s instructions precisely. Do not adjust your dosage without consulting your physician. Medication adherence is key to successful treatment.
Potential Side Effects
Common side effects include headache, diarrhea, and nausea. More serious, though less frequent, side effects can include irregular heartbeat and heart failure. Report any concerning symptoms to your doctor immediately. Regular check-ups allow for monitoring of your progress and adjustments to treatment if needed. Open communication with your physician ensures your safety and efficacy of treatment.
Important Considerations
Cilostazol is not suitable for everyone. Individuals with certain heart conditions, such as uncontrolled heart failure, should not take this medication. Before starting cilostazol, inform your doctor about all your health conditions, including any allergies, and any other medications you currently take. This helps to prevent harmful drug interactions.


