Hydroxyzine primarily works by blocking histamine receptors in the brain. This action reduces the effects of histamine, a neurotransmitter involved in anxiety and allergic reactions. Specifically, it’s a competitive antagonist at H1 receptors, meaning it competes with histamine for binding sites, preventing histamine from triggering its typical effects.
Impact on Anxiety
By reducing histamine activity, hydroxyzine helps calm the central nervous system, lessening anxiety symptoms. This effect also contributes to its sedative properties. The precise mechanisms contributing to its anxiolytic effect aren’t fully understood, but it likely involves interactions with other neurotransmitter systems beyond just histamine.
Sedative Effects
Hydroxyzine’s sedative effects are a direct consequence of its central nervous system depressant actions. This depression influences various brain regions associated with arousal and wakefulness. The degree of sedation varies depending on dosage and individual patient factors.
