RxList provides detailed information on Sildenafil, highlighting its uses in treating erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). Understanding the drug’s mechanism of action is key: Sildenafil inhibits phosphodiesterase-5 (PDE5), increasing blood flow to the penis for ED and improving blood flow to the lungs for PAH.
Dosage and Administration
Dosage varies depending on the condition being treated and individual patient factors. For ED, common starting dosages are 50mg, adjusted based on efficacy and tolerability. For PAH, dosing is typically higher and more individualized. Always follow your doctor’s prescribed dosage and instructions. Never exceed recommended dosages.
Side Effects
Common side effects include headache, flushing, nasal congestion, and visual disturbances. Serious, although rare, side effects include sudden vision loss, hearing loss, and prolonged erection (priapism). Seek immediate medical attention if you experience these.
Drug Interactions
| Nitrates | Dangerous drop in blood pressure. Avoid concurrent use. |
| Alpha-blockers | Increased risk of hypotension. Monitor blood pressure carefully. |
| CYP3A4 inhibitors | Increased Sildenafil levels. Dosage adjustment may be necessary. |
This table provides a snapshot; consult your doctor or pharmacist for a complete list of potential interactions.
Contraindications
Sildenafil is contraindicated for individuals with certain heart conditions, low blood pressure, uncontrolled hypertension, recent stroke or heart attack, retinitis pigmentosa, or hypersensitivity to Sildenafil. Pregnant and breastfeeding women should also avoid Sildenafil.
Further Information
This overview is intended for informational purposes only and does not replace professional medical advice. Always consult your doctor before starting any new medication, including Sildenafil. RxList provides a more thorough account of the drug’s properties and potential risks; refer to that resource for comprehensive details.
Warnings and Precautions
Patients should be aware of potential side effects and promptly report any unusual symptoms to their doctor. Regular monitoring may be necessary, especially for those with underlying health conditions. The information provided here should be supplemented with guidance from a healthcare professional.
