Short-Term and Long-Term Effects of Prednisone on Nasal Polyps and Overall Health

Prednisone shrinks nasal polyps quickly. You might notice reduced nasal congestion and improved breathing within days. This short-term benefit is often the primary reason for prescribing it.

Short-Term Effects

Expect improvements in nasal airflow and a decrease in polyp size within a week. Side effects, however, can include increased appetite, weight gain, mood swings, insomnia, and increased blood sugar. These are usually temporary and subside once the medication is stopped.

Long-Term Effects and Considerations

Long-term prednisone use for nasal polyps isn’t recommended due to significant side effects, including osteoporosis, cataracts, and increased risk of infection. Prolonged use can also suppress the immune system. While prednisone effectively reduces polyp size, it doesn’t address the underlying cause. Once you stop taking it, polyps often return. Your doctor will likely recommend a longer-term management strategy, possibly including surgery or other medications to prevent recurrence. Discuss all options carefully with your physician to develop a personalized treatment plan.