Regularly monitor patients for adverse reactions. Skin rashes, fever, and gastrointestinal upset are common. Severe reactions, such as Stevens-Johnson syndrome, are rare but serious.
Blood tests to monitor complete blood count (CBC) and kidney function (creatinine and BUN) are recommended, especially for patients with pre-existing kidney disease or those taking high doses. Frequency depends on individual risk factors; your doctor will advise.
- CBC Monitoring: Check for anemia, leukopenia, and thrombocytopenia. Adjust dosage or discontinue treatment if significant changes occur. Kidney Function Monitoring: Monitor serum creatinine and BUN levels. Dose adjustment or alternative therapy might be necessary if renal impairment develops or worsens.
Patients should be advised to report any unusual symptoms immediately. This includes skin changes, unexplained fatigue, or changes in urination.
Hydration: Encourage adequate fluid intake to reduce the risk of crystalluria (crystal formation in urine). Allergic Reactions: Discontinue treatment and seek immediate medical attention if an allergic reaction occurs. Drug Interactions: Be aware of potential interactions with other medications, particularly warfarin and methotrexate. Consult medication guides or your doctor for details.
For patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency, use caution as hemolytic anemia can occur. Alternative antibiotics should be considered.
Therapeutic drug monitoring (TDM) may be considered in certain situations, such as suspected treatment failure or severe renal impairment. Your doctor will determine if TDM is appropriate.
Closely following these guidelines helps ensure safe and successful treatment with sulfamethoxazole and trimethoprim.
