Low-dose naltrexone (LDN) influences weight loss by interacting with opioid receptors in your body. These receptors aren’t just involved in pain and addiction; they play a significant role in regulating appetite and metabolism.
How LDN Affects Opioid Receptors
Unlike high doses of naltrexone used to treat opioid addiction, LDN works differently. It partially blocks opioid receptors, leading to a complex cascade of effects. This partial blockade increases the body’s natural opioid production, influencing various systems, including those responsible for appetite control and fat metabolism.
Specific Receptor Types and Their Impact
The interaction with specific opioid receptor types, such as mu-opioid receptors (MOR) and delta-opioid receptors (DOR), is critical. A change in the activity of these receptors can affect the release of hormones and neurotransmitters that influence satiety and energy expenditure. While research is ongoing, current understanding points to a potential effect on hormones like leptin and ghrelin.
| Mu-opioid Receptor (MOR) | May influence appetite regulation and food intake. |
| Delta-opioid Receptor (DOR) | May affect energy expenditure and metabolism. |
Further Research and Considerations
The precise mechanisms by which LDN interacts with opioid receptors to promote weight loss require further investigation. Individual responses vary significantly. Consult with your doctor before starting LDN, especially if you have any underlying health conditions or are currently taking other medications.
