Always inform your doctor about all medications you’re taking, including over-the-counter drugs, herbal remedies, and supplements, before starting lamotrigine. This proactive approach helps prevent potentially harmful interactions.
Contraindicated Medications
Some drugs should not be taken with lamotrigine. Combining them increases the risk of serious side effects. These include: certain strong opioid pain relievers (e. g., methadone), and some antipsychotics (e. g., risperidone). Your doctor will discuss alternatives if necessary.
Medications Requiring Dosage Adjustments
Many medications can affect lamotrigine levels in your body, necessitating dose adjustments. This requires careful monitoring by your healthcare provider. These include:
| Hormonal contraceptives (birth control pills) | Ethinyl estradiol, levonorgestrel | May lower lamotrigine levels |
| Valproic acid (anticonvulsant) | Depakote, Depakene | May increase lamotrigine levels significantly |
| Rifampin (antibiotic) | Rifadin, Rimactane | May lower lamotrigine levels |
| Phenytoin (anticonvulsant) | Dilantin | May increase or decrease lamotrigine levels depending on the individual. |
Monitoring and Precautions
Regular blood tests may be needed to check your lamotrigine levels while taking other medications. Report any new or worsening symptoms to your doctor immediately. This includes rashes, dizziness, or unusual fatigue. Close monitoring ensures your safety and treatment efficacy. Remember, open communication with your doctor is crucial for managing your medication safely.
Disclaimer:
This information is for educational purposes only and does not constitute medical advice. Always consult your physician or pharmacist for guidance on drug interactions and medication management.
