Avoid combining Donepezil with medications that can lower heart rate or blood pressure. This includes certain beta-blockers, calcium channel blockers, and some antiarrhythmics. Always inform your doctor of all medications you are taking, including over-the-counter drugs and supplements.
Anticholinergic Drugs
Donepezil works by increasing acetylcholine levels in the brain. Anticholinergic medications have the opposite effect, blocking acetylcholine. Combining them can significantly reduce Donepezil’s effectiveness and potentially cause adverse effects. Examples include:
- Certain antihistamines (e. g., diphenhydramine) Some antispasmodics Tricyclic antidepressants
Discuss alternative medications with your doctor if you need these drug classes.
Strong CYP450 Inhibitors
Donepezil metabolism involves the CYP2D6 enzyme. Drugs that strongly inhibit CYP2D6 can increase Donepezil blood levels, potentially leading to increased side effects. Consult your physician before combining Donepezil with these inhibitors, which include:
Fluoxetine Paroxetine Quinidine
Your doctor may adjust your Donepezil dosage or choose an alternative medication.
NSAIDs and Other Medications
Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen can increase the risk of gastrointestinal bleeding when taken with Donepezil. This risk is especially high for individuals already prone to ulcers or gastrointestinal issues. Always inform your doctor of all medications you are considering, to discuss potential risks and alternatives.
This information is not exhaustive. Always consult your doctor or pharmacist before starting or stopping any medication while taking Donepezil HCL 10mg to ensure your safety and the effectiveness of your treatment.
