Sildenafil’s use in pulmonary fibrosis is off-label, meaning its dosage isn’t definitively established through large-scale clinical trials specifically for this indication. Prescribing physicians carefully consider individual patient factors to determine the appropriate regimen.
Typical Starting Dose and Adjustments
A common starting dose is 20 mg three times daily. Physicians may adjust this based on the patient’s response and tolerance. Some patients might benefit from a lower dose (e. g., 20 mg twice daily), while others may require higher doses (up to 80 mg three times daily), but this should only be done under close medical supervision.
Monitoring for Side Effects
Regular monitoring for side effects is critical. Common side effects include headache, flushing, and visual disturbances. If intolerable side effects occur, dose reduction or treatment discontinuation may be necessary. Patients should report any new or worsening symptoms immediately to their doctor.
Administration Guidelines
Sildenafil is typically administered orally, with or without food. The timing of administration may vary based on individual needs and the physician’s recommendations. Consistent adherence to the prescribed schedule is important for optimal therapeutic effect.
Important Considerations
Caution: Patients with severe hepatic or renal impairment require careful dose adjustment, as Sildenafil is metabolized primarily by the liver and excreted by the kidneys. Simultaneous use with certain medications, particularly nitrates, is contraindicated due to potentially dangerous interactions. Always discuss all medications and supplements with your physician before starting Sildenafil.
