Diflucan, containing fluconazole, combats Malassezia globosa, the fungus causing tinea versicolor, by inhibiting its growth. This happens through targeted disruption of fungal cell membrane synthesis.
Targeting Ergosterol Production
Fluconazole specifically blocks the enzyme lanosterol 14α-demethylase. This enzyme is crucial for ergosterol production, a vital component of the fungal cell membrane. Reduced ergosterol levels weaken the fungal cell membrane, compromising its integrity and hindering the fungus’s ability to function normally.
Impact on Fungal Growth and Reproduction
The weakened cell membrane leads to leakage of cellular components, ultimately inhibiting fungal growth and reproduction. This antifungal action effectively reduces the Malassezia globosa population, clearing the skin infection.
Selective Toxicity
Fluconazole demonstrates selective toxicity, meaning it primarily affects fungal cells and spares human cells. This is because human cells don’t synthesize ergosterol in the same way. However, individual reactions vary, and some side effects are possible.
Dosage and Treatment Duration
Consult your doctor for appropriate dosage and duration of treatment. The specific course will depend on the severity of your infection. Complete the prescribed course, even if symptoms improve prematurely to ensure a full cure.
