Rapid antigen detection tests (RADTs) remain the first-line diagnostic tool. However, a negative RADT doesn’t rule out strep throat, particularly if resistance is suspected. A throat culture provides definitive identification and allows for susceptibility testing to amoxicillin.
Susceptibility testing reveals whether the strep bacteria are resistant to amoxicillin. A positive result confirms amoxicillin resistance, guiding treatment decisions toward alternative antibiotics.
Clinical presentation is crucial. Symptoms like persistent fever, severe sore throat, or lack of response to amoxicillin treatment warrant further investigation, including culture and sensitivity testing.
Consider the patient’s history. Previous antibiotic use, especially amoxicillin, increases the likelihood of resistance. Knowing this informs your testing strategy.
Penicillin remains an effective alternative if susceptibility testing confirms sensitivity. If penicillin resistance is also present, cephalosporins or clindamycin are usually appropriate choices. Always refer to local antimicrobial guidelines for optimal treatment selection.
