For patients with hepatic impairment, reduce the dosage. Consult prescribing information for specific recommendations based on Child-Pugh classification. Avoid azithromycin in severe hepatic disease.
Renal Impairment
Dosage adjustments are usually unnecessary for patients with mild to moderate renal impairment. However, for those with severe renal impairment (creatinine clearance
Geriatric Patients
While generally well-tolerated, older adults might require dosage adjustments due to age-related changes in organ function. Closely monitor for adverse effects. Consider a lower starting dose or a longer dosing interval if necessary.
Pediatric Patients
Azithromycin dosage for children is weight-based. Always follow the recommendations outlined in pediatric prescribing information. The 250 mg tablet is usually inappropriate for young children.
Pregnancy and Lactation
Use azithromycin during pregnancy only when clearly needed. Assess the benefits and risks carefully. Similarly, exercise caution when prescribing azithromycin to breastfeeding mothers. Monitor the infant for potential adverse effects.
Drug Interactions
Azithromycin interacts with several medications, including some anticoagulants, ergot alkaloids, and certain antidepressants. Adjust the dosage or consider alternative medications as necessary to minimize interaction risks. Consult drug interaction resources for details.
